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What Is TRAMADOL?
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Tramadol is used for:
Treating moderate to moderately severe pain.
Tramadol is an analgesic. It works in certain areas of the brain and nervous system to decrease pain.
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This shows that I have learned relief from the pain, but most doctors do not want to admit it. What if tramadol is used with DOS and joints? TRAMADOL AAH PHARMA 100 mg / 2 ml solution for injection. Medicines commonly used to treat pain. In the rat, the tramadol 50 mg / kg mcg / day dose has a toxic effect on the skin, increasing the child's fatigue. In the case of delayed epidemics in the form of cubic disorder and vaginal opening and decay of the eye. This does not affect male fertility. At higher doses (greater than 50 mg / kg / day), pregnancy in women decreased. In rabbits, the toxic effect of dandruff is 125 mg / kg, skeletal abnormalities are revealed in offspring.
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The concomitant use of tramadol and acetaminophen and cimetidine tablets has not been studied. The combined administration of tramadol and cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Thus, the administration of tramadol and acetaminophen tablets has not changed.
Concomitant use of darunavir and tramadol can reduce the metabolism of tramadol to CYP3A4 and CYP2D6. In case of concomitant administration, the dose of tramadol may need to be reduced. These interactions may lead to a decrease in the effect of tramadol and / or an increased risk of tramadol or confusion of serotonin syndrome. CYP2D6 analgesic tramadol activity resulting from the use of Desmetylotramadolu Original (M1) M1 drugs and metabolites and training activities. Therefore, the combination of tramadol and the CYP2D6 inhibitor may affect the effect of tramadol. In addition, inhibition of one or both of CYP2D6 and CYP3A4 should reduce the metabolic clearance of tramadol. This may increase the risk of tramadol-associated adverse events, including serotonin syndrome and seizures. serotonin syndrome - rapid development of hyperthermia, hypertension, muscle spasms, stiffness, dysautonomia and the abnormal state of the state (eg delirium or coma), in exceptional cases, is death.
In children less than one year, the pharmacokinetics of tramadol and metiltramadola wasps were investigated but not completely characterized. Analysis of production data accelerates O-demethyltramadol in this age group, the newborn stable level of the adult population of CYP2D6 and CYP2D6 activity showed approximately one year. In addition, the immature kidney area of ??the glyukuronirovaniya system and immaturity, you can delay the accumulation of O-demethyltramadol in children under one year of age.
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