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however, people may attempt to inject, smoke, or snort it. The issue of the safety of prescribing stimulants is an important and controversial area. The present article aims to outline the controversies surrounding prescription of stimulants, with particular reference to sustained-release amphetamine salts in children with ADHD, and summarize current guidelines to use when prescribing a stimulant. NDC Product Information. According to the Texas A M University Health Science Center, Adderall helps lower stimulation levels of people with ADHD to help them function better. However, the drug can overstimulate people without attention disorders and cause stroke or death. It is known that oral clinical doses of MPH act to block the dopamine transporter in the striatum, increasing the availability of dopamine at the synapse. It has been hypothesized that in response to this increased dopamine availability, postsynaptic dopamine receptors are inactivated by a process of internalization (retracting into the cell membrane).11 One way to overcome this mechanism of tolerance is to provide a medication-free interval; when synaptic dopamine concentrations return to baseline levels, the receptors re-emerge from the cell membrane, reverting to their normal sensitive states. A second way is to use a larger dose of MPH to produce a larger increase in synaptic dopamine concentration to compensate for the desensitization of the receptor. Studies to elucidate the mechanisms of acute tolerance to MPH and to amphetamine are underway. Editor s note: another great study aid (that doesn t have any side effects) is Brainscape flashcards an adaptive platform for learning languages, sciences, mathematics, and more (you can even make your own cards). Check out the Brainscape flashcard decks and iOS apps at Brainscape.com. Suhr, J., Hammers, D., Dobbins-Buckland, K., Zimak, E. Hughes, C. (2008). The relationship of malingering test failure to self-reported symptoms and neuropsychological findings in adults referred for ADHD evaluation. Arch Clin Neuropsychol 23, 521-30. Patients should ask their doctor how and when to take Abilify. They

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